A Structural View of Integrin Activation and Signaling
نویسندگان
چکیده
منابع مشابه
Integrin activation and structural
141 Summary: Among adhesion receptor families, integrins are particularly important in biological processes that require rapid modulation of adhesion and de-adhesion. Activation on a timescale of 1s of b2 integrins on leukocytes and b3 integrins on platelets enables deposition of these cells at sites of inflammation or vessel wall injury. Recent crystal, nuclear magnetic resonance (NMR), and el...
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Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between tal...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2003
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(03)00034-0